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1

A growing role for mTOR in promoting anabolic metabolism

Howell, Jessica J., Ricoult, Stéphane J.H., Ben-Sahra, Issam, Manning, Brendan D.

Journal:

Biochemical Society Transactions

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

2

mTORC1 signaling and the metabolic control of cell growth

Ben-Sahra, Issam, Manning, Brendan D

Journal:

Current Opinion in Cell Biology

Year:

2017

Language:

english

File:

PDF, 962 KB

english, 2017

3

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H 2 S Production

Longchamp, Alban, Mirabella, Teodelinda, Arduini, Alessandro, MacArthur, Michael R., Das, Abhirup, Treviño-Villarreal, J. Humberto, Hine, Christopher, Ben-Sahra, Issam, Knudsen, Nelson H., Brace, Lear

Journal:

Year:

2018

Language:

english

File:

PDF, 5.57 MB

english, 2018

4

Direct stimulation of NADP + synthesis through Akt-mediated phosphorylation of NAD kinase

Hoxhaj, Gerta, Ben-Sahra, Issam, Lockwood, Sophie E., Timson, Rebecca C., Byles, Vanessa, Henning, Graham T., Gao, Peng, Selfors, Laura M., Asara, John M., Manning, Brendan D.

Journal:

Year:

2019

Language:

english

File:

PDF, 966 KB

english, 2019

5

The metabolic perturbators metformin, phenformin and AICAR interfere with the growth and survival of murine PTEN-deficient T cell lymphomas and human T-ALL/T-LL cancer cells

Rosilio, Célia, Lounnas, Nadia, Nebout, Marielle, Imbert, Véronique, Hagenbeek, Thijs, Spits, Hergen, Asnafi, Vahid, Pontier-Bres, Rodolphe, Reverso, Julie, Michiels, Jean-François, Ben Sahra, Issam,

Journal:

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

6

Metformin: A metabolic disruptor and anti-diabetic drug to target human leukemia

Rosilio, Célia, Ben-Sahra, Issam, Bost, Frédéric, Peyron, Jean-François

Journal:

Year:

2014

Language:

english

File:

PDF, 1.06 MB

english, 2014

7

mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms

Ben-Sahra, Issam, Ricoult, Stephane, Howell, Jessica, Asara, John, Manning, Brendan

Journal:

Cancer & Metabolism

Year:

2014

Language:

english

File:

PDF, 82 KB

english, 2014

8

The TSC-mTOR pathway regulates macrophage polarization

Byles, Vanessa, Covarrubias, Anthony J., Ben-Sahra, Issam, Lamming, Dudley W., Sabatini, David M., Manning, Brendan D., Horng, Tiffany

Journal:

Nature Communications

Year:

2013

Language:

english

File:

PDF, 790 KB

english, 2013

9

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis

Liu, Xue-Song, Haines, Jenna E., Mehanna, Elie K., Genet, Matthew D., Ben-Sahra, Issam, Asara, John M., Manning, Brendan D., Yuan, Zhi-Min

Journal:

Genes & Development

Year:

2014

Language:

english

File:

PDF, 2.12 MB

english, 2014

10

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

Ben Sahra, Issam, Tanti, Jean-François, Bost, Frédéric

Journal:

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

11

Metformin and cancer therapy

Bost, Frédéric, Sahra, Issam Ben, Le Marchand-Brustel, Yannick, Tanti, Jean-François

Journal:

Current Opinion in Oncology

Year:

2012

Language:

english

File:

PDF, 268 KB

english, 2012

12

The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia

Fenouille, Nina, Bassil, Christopher F, Ben-Sahra, Issam, Benajiba, Lina, Alexe, Gabriela, Ramos, Azucena, Pikman, Yana, Conway, Amy S, Burgess, Michael R, Li, Qing, Luciano, Frédéric, Auberger, Patri

Journal:

Nature Medicine

Year:

2017

Language:

english

File:

PDF, 2.53 MB

english, 2017

13

The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells

Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti,

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 2.04 MB

english, 2017

14

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Hoxhaj, Gerta, Hughes-Hallett, James, Timson, Rebecca C., Ilagan, Erika, Yuan, Min, Asara, John M., Ben-Sahra, Issam, Manning, Brendan D.

Journal:

Year:

2017

Language:

english

File:

PDF, 5.44 MB

english, 2017

15

Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation

Covarrubias, Anthony J, Aksoylar, Halil Ibrahim, Yu, Jiujiu, Snyder, Nathaniel W, Worth, Andrew J, Iyer, Shankar S, Wang, Jiawei, Ben-Sahra, Issam, Byles, Vanessa, Polynne-Stapornkul, Tiffany, Espinos

Journal:

Year:

2016

Language:

english

File:

PDF, 2.43 MB

english, 2016

16

HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth

Ben-Sahra, Issam, Puissant, Alexandre

Journal:

Cell Metabolism

Year:

2018

Language:

english

File:

PDF, 536 KB

english, 2018

17

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

Yuan, Min, Kremer, Daniel M., Huang, He, Breitkopf, Susanne B., Ben-Sahra, Issam, Manning, Brendan D., Lyssiotis, Costas A., Asara, John M.

Journal:

Nature Protocols

Year:

2019

File:

PDF, 2.14 MB

2019

18

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Zhang, Shuang, Weinberg, Samuel, DeBerge, Matthew, Gainullina, Anastasiia, Schipma, Matthew, Kinchen, Jason M., Ben-Sahra, Issam, Gius, David R., Charvet, Laurent Yvan-, Chandel, Navdeep S., Schumacke

Journal:

Cell Metabolism

Year:

2018

Language:

english

File:

PDF, 4.33 MB

english, 2018

19

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides

Villa, Elodie, Ali, Eunus, Sahu, Umakant, Ben-Sahra, Issam

Journal:

Year:

2019

Language:

english

File:

PDF, 1.49 MB

english, 2019

20

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

Ali, Eunus S., Sahu, Umakant, Villa, Elodie, OâHara, Brendan P., Gao, Peng, Beaudet, Cynthia, Wood, Antony W., Asara, John M., Ben-Sahra, Issam

Journal:

Year:

2020

File:

PDF, 4.53 MB

2020

21

A spoonful of DHAP keeps mTORC1 running on sugars

Hoxhaj, Gerta, Locasale, Jason W., Ben-Sahra, Issam

Journal:

Nature Metabolism

Year:

2020

File:

PDF, 887 KB

2020

22

ASS1igning purine dependency to cancer

Villa, Elodie, Ben-Sahra, Issam

Journal:

Year:

2020

File:

PDF, 810 KB

2020

23

DRES-09. REGULATORY EFFECTS OF THE CILIARY GTPASE ARL13B ON PURINE METABOLISM IN GBM

Saathoff, Miranda, Shireman, Jack, Ali, Eunus, Park, Cheol, Ben-Sahra, Issam, Ahmed, Atique

Journal:

Year:

2019

File:

PDF, 96 KB

2019

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